PTEN is an important cellular enzyme that is frequently mutated in cancer. In normal cells, it downregulates signaling though the PI3-kinase pathway that controls cell proliferation. When PTEN is mutated, the PI3 pathway becomes overactive, which can contribute to cancer. This volume examines advances in our understanding of the functions of the PTEN protein, is regulation, and how loss of PTEN can promote the development and progression of different cancers.

Topics covered in this essential volume include:

- Structural Mechanisms of PTEN Regulation - The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes - PTEN Mouse Models of Cancer Development and Progression - Autism Spectrum Disorder Associated with Germline Heterozygous PTEN Mutations - PTEN Diagnostics: A Systems Pathology Approach

Joanne Ngeow's profile page

Charis Eng's profile page

Vuk Stambolic's profile page

Joanne Ngeow is with the National Cancer Centre Singapore.

Charis Eng is with the Genomic Medicine Institute, Lerner Research Institute.

Vuk Stambolic is with the Princess Margaret Cancer Centre.