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Medical Neuroscience

The Oxford Handbook of Neuronal Protein Synthesis

by (author) Wayne S. Sossin

Oxford University Press
Initial publish date
Apr 2021
  • Hardback

    Publish Date
    Apr 2021
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Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.

About the author

Contributor Notes

Dr. Sossin received undergraduate degrees in Biology and Computer Science from MIT in 1984 and completed his PhD at Stanford in Biological Sciences with Dr. Richard Scheller in 1989. He did post-doctoral work with Dr. Schwartz at Columbia Univeristy in the Center for Neurobiology and Behavior before being appointed Assistant Professor at the Montreal Neurological Institute at McGill University in 1993 where he is now a James McGill Professor. He has been an EJLB Scholar, CIHR investigator and FRSQ Checheur Nationaux. Dr. Sossin has published over 125 papers on the molecular and cellular processes underlying memory formation and maintenance with a particular interest in the role of persistent protein kinases and the regulation of local translation in this process.