When investigative journalist Isabel Morgan vanishes, her colleagues and lovers see this as just another gambit in her ever dramatic life. But her closest friend, Leo Holland, a Manhattan cartoonist, is filled with a sense of dread: something terrible has happened to Isabel. She is more certain of this than of much else in a life that is teetering close to the edge. In desperation, she flies to London to trace the woman she realizes has become her sustaining force.Convinced that Isabel's disappearance is tied in some way to the genetically modified substances she has been investigating and that her analyst holds the keys to her whereabouts, Leo masquerades as a potential patient. In the process, she discovers more than she set out to know. Danger, in Isabel's secret world, comes in many guises.