The letters in this volume cover Erasmus' correspondence from March to December 1527. These 129 letters centre primarily on Erasmus' continuing struggle with his Catholic critics, especially those in Spain and France, and on Erasmus' growing criticism of the Protestant reform movement.

The letters show Erasmus' attempts to justify his position and to win favour with rulers, other prestigious men, and powerful institutions, all influential in both secular and religious spheres. Although the Inquisition in Spain investigated his orthodoxy and did not bring charges against him, the Paris Faculty of Theology formally condemned 112 propositions drawn from Erasmus' works in December 1527. The letters in this volume, written by and to Erasmus in this critical time, represent a unique view of a Europe torn by war and breaking apart into religious confessionalism and regionally organized churches.

Throughout all this controversy, Erasmus repeatedly protested that the sole aim of his life's work was to promote the study of humanities for the profit of both knowledge and religion.

Desiderius Erasmus (c. 1466–1536), a Dutch humanist, Catholic priest, and scholar, was one of the most influential Renaissance figures. A professor of divinity and Greek, Erasmus wrote, taught, and travelled, meeting with Europe’s foremost scholars. A prolific author, Erasmus wrote on both ecclesiastic and general human interest subjects.

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Charles Fantazzi is a professor in the Department of Foreign Languages and Literatures at East Carolina University and a professor emeritus in the Department of Classics at the University of Windsor.

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