Wilfred Grenfell arrived in Labrador in 1892 as the agent of the National Mission to Deep Sea Fishermen. His immediate task was to provide a system of medical care for migratory fishermen living apart from their Newfoundland communities. But in the course of his life, Grenfell proceeded to build a complex medical and philanthropic organization that still bears his name a century later. By 1908, he had already laid the foundation for a missionary domain with its headquarters in St. Anthony and was expanding his influence through home industries and other social reforms designed to transform the region economically.